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avana six pines ratings Exon 20, a component of BRCA 1(Breast Cancer Associated gene), mutates to disrupt the structural stability of proteins, causing cancerous cells to proliferate, the research shows. It hastens the development of breast cancer and could be specific to the eastern region of the country, believe the researchers. A paper on Exon 20 mutation, which has so far not been reported from anywhere in the world, will be published in the prestigious international journal, Cellular & Molecular Biology Letters, next month.